Nutritional and Biochemical Aspects of Vitamin B6: Implications for Epilepsy and Health"

Abstract: Food is necessary for humans to synthesize vitamin B6, which is a water-soluble essential vitamin that must be obtained through diet. PLP, an active form of vitamin B6 among the six interconvertible compounds, is primarily found in meat and fish. It is particularly well known for its role in the synthesis of neurotransmitters such as dopamine from L-DOPA, serotonin from 5-HTP, and GABA from glutamate. Vitamin B6 is essential for mental health, and pyridoxine is derived from plants. PLP is the only vitamin B6 that works as a cofactor and coenzyme in many neurological reactions; thus, its deficiency is associated with several neurological disorders. Seizures are a sign of newborn epilepsy in 10% to 15% of babies, typically brought on by cortical abnormalities, genetic flaws, or inborn metabolic mistakes. This review focuses on nutritional sources, biochemical properties, and the many forms of epilepsy caused by Vitamin B6 deficiency. ALDH7A1 deficiency, hyperprolinaemia type II, Pyridoxamine Phosphate Oxidase deficiency, PLP-Binding Protein disorder, hypophosphatasia, and glycosylphosphatidylinositol anchor synthesis defect are among the vitamin B6-dependent epilepsy conditions that can be treated with PLP or pyridoxine. Based on the effects of Vitamin B6, we conclude that after identifying epilepsy symptoms in neonates, administer pyridoxine right away if the patient does not respond to the antiepileptic medications. This review offers advice and raises awareness on Vitamin B6 among health care professionals and information seekers.