How to use novel antimicrobials beyond official indications: an expert consensus
This consensus supports the judicious off-label use of new antimicrobials in specific clinical scenarios where therapeutic gaps exist. The guidance prioritizes targeted treatment over empirical use, aligning with international ASP principles and WHO recommendations. These results provide a regional reference to optimize ASP initiatives focus on new antibiotic use while minimizing ecological impact and resistance development.
Authors
- Julia Praena‐Segovia
- Ignacio Márquez-Gómez (ORCID: https://orcid.org/0000-0002-9555-5767)
- Andrés Martín-Aspas (ORCID: https://orcid.org/0000-0002-3086-9095)
- M Ángeles Esteban-Moreno
- Svetlana Sadyrbaeva-Dolgova
- Juan E. Corzo-Delgado
- Lucía Valiente de Santis
- Patricia Jiménez-Aguilar (ORCID: https://orcid.org/0000-0003-0965-285X)
- Pilar Retamar (ORCID: https://orcid.org/0000-0003-2147-809X)
- Salvador López-Cárdenas (ORCID: https://orcid.org/0000-0002-6090-033X)
- Juan José Castón-Osorio
- Jesús Rodríguez‐Baño (ORCID: https://orcid.org/0000-0001-6732-9001)
- Francisco Javier Martínez‐Marcos
- Zaira R. Palacios‐Baena (ORCID: https://orcid.org/0000-0002-1713-6807)
- Francisco Anguita-Santos (ORCID: https://orcid.org/0000-0002-9574-0778)
- Guillermo Ojeda (ORCID: https://orcid.org/0000-0003-0544-4690)
- Carmen Herrero‐Rodríguez
- María Alegre-Albendea
Institutions
- Universidad de La Frontera (CL)
- Instituto de Salud Carlos III (ES)
- Hospital Universitario Virgen Macarena (ES)
- Instituto Maimónides de Investigación Biomédica de Córdoba (ES)
- Hospital Regional Universitario de Málaga (ES)
- Instituto de Investigación Biosanitaria de Granada (ES)
- Hospital Universitario Virgen de las Nieves (ES)
- Complejo Hospitalario de Jaén (ES)
- Biomedical Research and Innovation Institute of Cadiz (ES)
- Hospital Juan Ramón Jiménez (ES)
- Instituto de Biomedicina de Sevilla (ES)
- Hospital Universitario Puerto Real (ES)
- Hospital Universitario de Valme (ES)
- Complejo Hospitalario Torrecárdenas (ES)
- Hospital Jerez Puerta del Sur (ES)
- Hospital Clínico Universitario Virgen de la Victoria (ES)
Publication Details
- Journal
- JAC-Antimicrobial Resistance
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1093/jacamr/dlaf184
- Primary Topic
- Pharmaceutical studies and practices
- Type
- article
- Field-Weighted Citation Impact
- 0.00