Carboxymethylated Quinoa Starch-Naringin Loaded Nanoparticles: Preparation and Evaluation

Aim: Carboxymethylated quinoa starch nanoparticles loaded with naringin were prepared using the rapid and reliable nanoprecipitation method with the aim of enhancing the drug's solubility and release. Background: Naringin is widely used as an anti-inflammatory agent and is also beneficial in the management of obesity, diabetes, hypertension, and metabolic syndrome. It is used as a model drug in this study. Objective: The objective of this study is to increase the solubility and release of the drug. Carboxymethylated quinoa starch nanoparticles loaded with naringin were created using a quick and dependable nanoprecipitation process. Methods: Quinoa seed starch was extracted through the water steeping method. Naringinloaded Carboxymethylated Starch Nanoparticles (NCMSNPs) loaded with model drug naringin were prepared to enhance the solubility of the drug by using the nanoprecipitation technique. Blank and naringin-loaded carboxymethylated starch nanoparticles were prepared by the nanoprecipitation technique, containing 0.5-4.5%w/v Carboxymethylated starch and 0.5%w/v drug. Results: The selected batch based on minimum particle size, minimum PDI, and maximum % entrapment efficiency was assessed for in-vitro drug release profile, anti-inflammatory activity, and anti-oxidant activity. The in-vitro anti-inflammatory activity and antioxidant activity of NCMSNPs were observed to be higher (95.50%, 62%) than those of the pure drug (73.03%, 53%). The drug release profile of NCMSNPs revealed maximum drug release of 88.19% over a specified period of 24 h in phosphate buffer (pH-6.8) as compared to 42.62% release from drug solution following the NCMSNPs “n” value was found to be (n>0.5), which shows the release of drug from NCMSNPs occurs by the mechanism of Super case II transport diffusion. Conclusion: Therefore, carboxymethylated quinoa starch possesses excellent potential as a carrier that can be explored for future applications in the field of pharmaceutical research.