GABA Modulation and Neuroprotection: Asteraceae as a Phytotherapeutic Avenue for Epilepsy

Introduction: Epilepsy is a chronic neurological condition characterized by the occurrence of recurrent seizures, affecting a substantial portion of the global population. Despite significant progress in the development of antiepileptic drugs and various surgical interventions, many patients continue to seek alternative therapeutic modalities. This trend is often attributed to complications, such as drug resistance and the adverse effects associated with conventional treatments. Methodology: The present review systematically examines bioactive compounds derived from prominent species within the Asteraceae family, including but not limited to Tanacetum parthenium, Artemisia absinthium, and Matricaria chamomilla. An exploration of the mechanisms underlying their actions was also conducted, focusing on their roles in modulating neuronal excitability, enhancing GABAergic activity, and alleviating oxidative stress. Results and Discussions: The therapeutic efficacy of plants belonging to the Asteraceae family in the management of epilepsy was explored, emphasizing their neuroprotective, anticonvulsant, and anti-inflammatory properties, which may offer viable adjunctive options for patients by modulating neuronal activity, enhancing GABAergic function, and reducing oxidative stress. Conclusion: The potential of Asteraceae species as adjunctive therapies for epilepsy is supported by preliminary findings. Future investigations should prioritize clinical trials and the establishment of standardized protocols to facilitate the integration of these herbal interventions into contemporary epilepsy treatment paradigms.