Aged and Young Adult Rats Respond Similarly to Highly Selective Neurokinin 2 Receptor Agonists That Produce Urination and Defecation Without Producing Cardiovascular Side Effects

The results show that GR64349 could be a promising therapeutic for inducing urination and defecation in the elderly without side effects such as hypotension.

Authors

Karl B. Thor (ORCID: https://orcid.org/0000-0001-5482-5241)
Raymond Piatt
Jason B. Cook (ORCID: https://orcid.org/0000-0002-8048-9373)
Lesley Marson

Institutions

Dignify Therapeutics (United States) (US)

Publication Details

Journal: Neurourology and Urodynamics
Published: 2025-11-26
DOI: https://doi.org/10.1002/nau.70188
Primary Topic: Urinary Bladder and Prostate Research
Type: article
Field-Weighted Citation Impact: 0.00

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article

Aged and Young Adult Rats Respond Similarly to Highly Selective Neurokinin 2 Receptor Agonists That Produce Urination and Defecation Without Producing Cardiovascular Side Effects

Karl B. Thor, Raymond Piatt, Jason B. Cook, Lesley Marson

Nov 26, 2025

Neurourology and Urodynamics

Urinary Bladder and Prostate Research

article

Aged and Young Adult Rats Respond Similarly to Highly Selective Neurokinin 2 Receptor Agonists That Produce Urination and Defecation Without Producing Cardiovascular Side Effects

Karl B. Thor, Raymond Piatt, Jason B. Cook, Lesley Marson

November 26, 2025article en

Abstract

The results show that GR64349 could be a promising therapeutic for inducing urination and defecation in the elderly without side effects such as hypotension.

Neurourology and UrodynamicsVol. 45(1)

Dignify Therapeutics (United States) (US)

Openalex Percentile: Top 50%

Urinary Bladder and Prostate Research

DOI Source OpenAlex

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Aged and Young Adult Rats Respond Similarly to Highly Selective Neurokinin 2 Receptor Agonists That Produce Urination and Defecation Without Producing Cardiovascular Side Effects — Karl B. Thor, Raymond Piatt, et al. · Neurourology and Urodynamics (2025) | TGRS Research Map | TGRS