Potential Utility of Micronucleus and Binucleus Frequencies in Malignancy Prediction in Thyroid Nodules
MN and BN cell frequencies were elevated in malignant nodules and higher Bethesda categories, supporting their potential role as adjunctive cytogenetic markers in thyroid nodule assessment. While findings are promising, their diagnostic utility in indeterminate nodules remains unclear. Larger, FNAB-based studies are required to validate their feasibility and clinical relevance in routine preoperative evaluation.
Authors
- Makbule Nihan Somuncu (ORCID: https://orcid.org/0000-0001-6041-457X)
- Fakih Cihat Eravcı (ORCID: https://orcid.org/0000-0001-9092-7923)
- Ayşe Gül Zamanı (ORCID: https://orcid.org/0000-0003-0329-9047)
- Rukiye Özçelik Erdem (ORCID: https://orcid.org/0000-0001-5087-4652)
- Hamdi Arbağ (ORCID: https://orcid.org/0000-0001-6146-8801)
- Hilmi Alper (ORCID: https://orcid.org/0000-0002-1188-1814)
Institutions
- Necmettin Erbakan University (TR)
Publication Details
- Journal
- Head & Neck
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1002/hed.70110
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00