Impact of elexacaftor/tezacaftor/ivacaftor on biomarkers of cystic fibrosis hepatobiliary involvement in the PUSH study
GGT and GPR improve in pwCF and CFHBI who received ETI compared to noETI. There were no changes in other liver parameters. This suggests an early signal for positive impact on CFHBI, but no early improvement in fibrosis.
Authors
- Sarah Jane Schwarzenberg (ORCID: https://orcid.org/0000-0001-5077-7625)
- Marilyn J. Siegel (ORCID: https://orcid.org/0000-0002-8342-8293)
- Molly Bozic (ORCID: https://orcid.org/0000-0002-3644-5381)
- Jennifer L. Nicholas (ORCID: https://orcid.org/0000-0003-0488-5945)
- Alexander J. Towbin (ORCID: https://orcid.org/0000-0003-1729-5071)
- Joseph J. Palermo (ORCID: https://orcid.org/0000-0001-5962-190X)
- Estella M. Alonso (ORCID: https://orcid.org/0000-0002-4056-7752)
- Adina Alazraki (ORCID: https://orcid.org/0000-0003-1094-282X)
- Nicole Green (ORCID: https://orcid.org/0000-0002-0371-0986)
- Randolph K. Otto (ORCID: https://orcid.org/0000-0003-1273-7176)
- John C. Magee (ORCID: https://orcid.org/0000-0001-8416-7905)
- Wikrom W. Karnsakul (ORCID: https://orcid.org/0000-0001-7288-5459)
- Shruti Paranjape
- Roger K. Harned (ORCID: https://orcid.org/0000-0001-8134-3301)
- Boaz Karmazyn (ORCID: https://orcid.org/0000-0003-1674-1789)
- Oscar M. Navarro (ORCID: https://orcid.org/0000-0001-8910-0304)
- Simon C. Ling (ORCID: https://orcid.org/0000-0002-4223-4601)
- A. Jay Freeman (ORCID: https://orcid.org/0000-0002-3399-3390)
- Wen Ye
- Suiyuan Huang
- Daniel H. Leung (ORCID: https://orcid.org/0000-0002-2139-5959)
- Prakash Masand
- Michael R. Narkewicz (ORCID: https://orcid.org/0009-0002-7645-4685)
- Janis M. Stoll (ORCID: https://orcid.org/0000-0001-9689-4675)
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- Fairview Health Services (US)
- Nationwide Children's Hospital (US)
- Johns Hopkins University (US)
- Columbus State Community College (US)
- University of Toronto (CA)
- Washington University in St. Louis (US)
- University of Michigan (US)
- Johns Hopkins Medicine (US)
- Hospital for Sick Children (CA)
- Riley Hospital for Children (US)
- Children's Hospital Colorado (US)
- Mallinckrodt (United States) (US)
- Seattle Children's Hospital (US)
- Lurie Children's Hospital (US)
- SickKids Foundation (CA)
- Children's Healthcare of Atlanta (US)
- Texas Children's Hospital (US)
- Johns Hopkins Hospital (US)
- Indiana University – Purdue University Indianapolis (US)
- University of Cincinnati Medical Center (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Journal of Pediatric Gastroenterology and Nutrition
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1002/jpn3.70290
- Primary Topic
- Cystic Fibrosis Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 0.00