Long-term accrual of conditions following myocardial infarction: a study of disease trajectories in the Wales Multimorbidity e-Cohort
Patients with MI have a high pre-existing multimorbidity burden that increases post-MI. Using NMF, we were able to reduce the real-world complexity of all individual diseases accrued over time into 10 latent post-MI multimorbidity trajectories. These trajectories were characterised by specific patterns of acute and chronic conditions, with differential impact on outcomes. These trajectories may enable the implementation of targeted strategies for individuals that are at greatest risk of adverse outcomes.
Authors
- Marlous Hall (ORCID: https://orcid.org/0000-0003-1246-2627)
- Jonathan A. Batty (ORCID: https://orcid.org/0000-0003-4102-5418)
- Christopher Hayward (ORCID: https://orcid.org/0000-0002-2666-5073)
- Chris P Gale (ORCID: https://orcid.org/0000-0003-4732-382X)
- Niels Peek (ORCID: https://orcid.org/0000-0002-6393-9969)
- Ronan A Lyons (ORCID: https://orcid.org/0000-0001-5225-000X)
Institutions
- Leeds General Infirmary (GB)
- University of Leeds (GB)
- University of Cambridge (GB)
- Manchester Academic Health Science Centre (GB)
- University of Manchester (GB)
- Swansea University (GB)
- Leeds Dental Hospital (GB)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1186/s12916-025-04520-1
- Primary Topic
- Chronic Disease Management Strategies
- Type
- article
- Field-Weighted Citation Impact
- 0.00