Photoredox/NHC-catalyzed remote alkylation of γ-functionalized enals with <i>N</i> -substituted pyridinium salts

We report a dual photoredox/NHC-catalyzed method for the regioselective remote alkylation of γ-functionalized enals. Using abundant Katritzky pyridinium salts as alkyl radical precursors and γ-functionalized enals to form trienolate intermediates, this method delivers the corresponding ε-alkyl-α,β-γ,δ-unsaturated esters in moderate to good yields. This strategy features mild conditions and a broad substrate scope, providing an efficient approach for remote alkylation reactions.