Not all penile tumours are alike: A rare case of penile melanoma

Penile melanoma is a rare neoplasm with aggressive biological behaviour and a dismal prognosis. We report the case of a 65-year-old male with a pigmented nodular lesion on the glans. Histopathology confirmed the diagnosis of penile melanoma with adverse prognostic features. Lymph node involvement was already present at diagnosis. He underwent partial penectomy and robotic-assisted laparoscopic bilateral inguinal and pelvic lymph node dissection, following confirmation of lymphatic spread by fine needle aspiration cytology. Thereafter, he received adjuvant radiotherapy and was started on nivolumab. This case highlights the importance of multimodal treatment, with no recurrence after 15 months of follow-up.

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Publication Details

Journal
Urology Case Reports
Published
2025-11-26
DOI
https://doi.org/10.1016/j.eucr.2025.103294
Primary Topic
Cutaneous Melanoma Detection and Management
Type
article
Field-Weighted Citation Impact
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article

Not all penile tumours are alike: A rare case of penile melanoma

M. Gil, J. Cabrita Carneiro, Ana Vaneska Passos Meireles, Luís Campos Pinheiro
Urology Case Reports
Cutaneous Melanoma Detection and Management
article

Not all penile tumours are alike: A rare case of penile melanoma

M. Gil, J. Cabrita Carneiro, Ana Vaneska Passos Meireles, Luís Campos Pinheiro
article en

Abstract

Penile melanoma is a rare neoplasm with aggressive biological behaviour and a dismal prognosis. We report the case of a 65-year-old male with a pigmented nodular lesion on the glans. Histopathology confirmed the diagnosis of penile melanoma with adverse prognostic features. Lymph node involvement was already present at diagnosis. He underwent partial penectomy and robotic-assisted laparoscopic bilateral inguinal and pelvic lymph node dissection, following confirmation of lymphatic spread by fine needle aspiration cytology. Thereafter, he received adjuvant radiotherapy and was started on nivolumab. This case highlights the importance of multimodal treatment, with no recurrence after 15 months of follow-up.

Urology Case ReportsVol. 64
Hospital de São José (PT), Administração Regional de Saúde de Lisboa e Vale do Tejo (PT)
Openalex Percentile: Top 50%
Cutaneous Melanoma Detection and Management
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