Human herpesvirus 7 induced aseptic meningitis in an immunocompetent adult presenting with unusual neurological symptoms: a case report

We report a rare case of viral meningitis induced by HHV-7 in a 37-year-old immunocompetent female, whose initial symptoms were unusual, presenting primarily with lower limb pain and numbness. Laboratory tests revealed HHV-7 deoxyribonucleic acid (DNA) in the CSF, confirming the diagnosis of aseptic meningitis. This case emphasizes the importance of considering HHV-7 in the differential diagnosis of viral meningitis, even without classic systemic signs. Despite the absence of specific antiviral therapy for HHV-7, supportive care remains effective. This case adds to the growing evidence on HHV-7 as an under-recognized cause of aseptic meningitis, particularly in immunocompetent individuals.

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Publication Details

Journal
Virology Journal
Published
2025-11-26
DOI
https://doi.org/10.1186/s12985-025-03025-w
Primary Topic
Cytomegalovirus and herpesvirus research
Type
article
Field-Weighted Citation Impact
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article

Human herpesvirus 7 induced aseptic meningitis in an immunocompetent adult presenting with unusual neurological symptoms: a case report

Cam Anh Nguyen Le, Thi Hong Phuong Nguyen, Pham Mai Anh Nguyen
Virology Journal
Cytomegalovirus and herpesvirus research
article

Human herpesvirus 7 induced aseptic meningitis in an immunocompetent adult presenting with unusual neurological symptoms: a case report

Cam Anh Nguyen Le, Thi Hong Phuong Nguyen, Pham Mai Anh Nguyen
article en

Abstract

We report a rare case of viral meningitis induced by HHV-7 in a 37-year-old immunocompetent female, whose initial symptoms were unusual, presenting primarily with lower limb pain and numbness. Laboratory tests revealed HHV-7 deoxyribonucleic acid (DNA) in the CSF, confirming the diagnosis of aseptic meningitis. This case emphasizes the importance of considering HHV-7 in the differential diagnosis of viral meningitis, even without classic systemic signs. Despite the absence of specific antiviral therapy for HHV-7, supportive care remains effective. This case adds to the growing evidence on HHV-7 as an under-recognized cause of aseptic meningitis, particularly in immunocompetent individuals.

Virology JournalVol. 22(1)
Vinmec Times City International Hospital (VN), VinUniversity (VN)
Openalex Percentile: Top 52%
Cytomegalovirus and herpesvirus research
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Human herpesvirus 7 induced aseptic meningitis in an immunocompetent adult presenting with unusual neurological symptoms: a case report — Cam Anh Nguyen Le, Thi Hong Phuong Nguyen, et al. · Virology Journal (2025) | TGRS Research Map | TGRS