Iron Deficiency Impairs Muscle Stem Cell Proliferation and Skeletal Muscle Regeneration via HIF‐2α Stabilization
Iron deficiency impairs skeletal muscle regeneration by stabilizing HIF-2α in MuSC, inducing Rb1 RNA expression, and repressing E2F-dependent proliferation. Transient HIF-2α inhibition rescues MuSC proliferation and muscle repair under iron-deficient conditions, highlighting HIF-2α as a potential therapeutic target to counteract sarcopenia in aging and chronic diseases.
Authors
- Yang Liu (ORCID: https://orcid.org/0000-0001-8364-1476)
- Wenyan Fu
- Liwei Xie (ORCID: https://orcid.org/0000-0002-4747-1753)
- Hang Yin (ORCID: https://orcid.org/0000-0002-9621-0138)
- Amelia Yin
Institutions
- University of Georgia (US)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1002/jcsm.70124
- Citations
- 1
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Institutes of Health
- National Institute of Arthritis and Musculoskeletal and Skin Diseases