A scalable approach for constructing bicyclic hydantoin structures to synthesize crucial intermediates for <scp>d</scp> -biotin
This study reports a new method to synthesize the key bicyclic thiazolidine hydantoin intermediate of d -biotin using N -benzyl-1 H -imidazole-1-carboxamide, which provides a scalable and industrially viable route to its derivatives.
Authors
- Weifeng Xia (ORCID: https://orcid.org/0000-0003-3148-8259)
- Xiangjun Shi (ORCID: https://orcid.org/0000-0001-9439-9507)
- Qin Zou (ORCID: https://orcid.org/0000-0003-4663-372X)
- Weike Su
- Shao‐Hsing Weng
- Zhen Liang (ORCID: https://orcid.org/0000-0003-3887-7804)
Institutions
- Zhejiang University of Technology (CN)
Publication Details
- Journal
- Reaction Chemistry & Engineering
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1039/d5re00319a
- Primary Topic
- Biotin and Related Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00