<scp>PLAGL1</scp> overexpression exacerbates type 1 diabetes by inducing β‐cell apoptosis via oxidative stress‐dependent dual <scp>DNA</scp> damage and <scp>cGAS</scp> / <scp>STING</scp> pathway activation
Our findings demonstrated that PLAGL1 exacerbates β-cell loss in type 1 diabetes by driving oxidative DNA damage and activating the cGAS/STING signaling cascade. Therapeutic intervention targeting this axis may therefore represent a promising strategy to protect β-cells and attenuate disease progression.
Authors
- Cheng Li (ORCID: https://orcid.org/0009-0009-7349-6776)
- Li Tang (ORCID: https://orcid.org/0000-0001-5468-985X)
- Hongxiu Yang
- Lingyan Qiao (ORCID: https://orcid.org/0009-0000-2815-8668)
- Sicui Hu (ORCID: https://orcid.org/0000-0002-2631-0117)
- Conghui Hu (ORCID: https://orcid.org/0000-0002-7085-6248)
- Juan Ge
Institutions
- Qingdao University (CN)
- Qingdao Women and Children's Hospital (CN)
Publication Details
- Journal
- Journal of Diabetes Investigation
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1111/jdi.70204
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00