Synthesis, Antibacterial, and Antioxidant Evaluation of Selenium‐Containing Spiro Derivatives With a Rare Triazaacenaphthylene Core

ABSTRACT In the present work, a two novel series of spiro ‐selena[3,5,8]triazaacenaphthylene derivatives 3a‐i and selena‐3,5,8‐triazaacenaphthylene‐2‐carbonitrile 5a‐f were obtained via a simple and eco‐friendly acid‐catalyzed procedure through the condensation of selenopheno[2,3‐b]pyridine 1 with alicyclic/aryl/heteroaryl ketones 2a‐i and/or aryl methyl ketones 4a‐f , respectively. The products were tested for antibacterial activity against four strains of bacteria ( Bacillus cereus (+G), Staphylococcus aureus (+G), Pseudomonas aeruginosa (−G), and Escherichia coli (−G)), with Ciprofloxacin serving as a reference drug, demonstrating strong activity, especially for spiro‐derivative 3f and triazaacenaphthylene 5f . Furthermore, DPPH antioxidant studies with vitamin C as a positive control were performed, indicating that spiro ‐derivative 3d and triazaacenaphthylene 5a had significantly higher redox activity (52% scavenging) compared to ascorbic acid (74%).