Tryptophan‐Derived Microbial Metabolite Indole‐3‐Acetic Acid Ameliorates Periodontitis Through <scp>AhR</scp> / <scp>CYP1A1</scp> ‐Mediated Macrophage Polarisation
These findings highlight the potential role of the microbial metabolite IAA in the development and treatment of periodontitis, offering a new perspective for intervention strategies based on microbial metabolites for periodontitis.
Authors
- Shuyu Cheng (ORCID: https://orcid.org/0000-0001-6547-1864)
- Yangheng Zhang (ORCID: https://orcid.org/0000-0002-2151-1737)
- Shiyuan Song
- Wenrong Yang (ORCID: https://orcid.org/0000-0001-8815-1951)
- Jiajie Pu (ORCID: https://orcid.org/0000-0002-3638-9228)
- Zhifeng Wang (ORCID: https://orcid.org/0000-0002-1153-4337)
- Wen Zhang (ORCID: https://orcid.org/0000-0002-8867-3677)
- Min Wang (ORCID: https://orcid.org/0000-0002-7431-8260)
- Fuhua Yan (ORCID: https://orcid.org/0000-0002-6963-3530)
- Dan Qiao (ORCID: https://orcid.org/0000-0002-4314-8596)
Institutions
- Deakin University (AU)
- Qinghai University Affiliated Hospital (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Journal Of Clinical Periodontology
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1111/jcpe.70064
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Nanjing University