Complement-independent pathogenic influences of anti-HMGCR + and anti-SRP + immune-mediated necrotizing myopathy autoantibodies on engineered muscle function
This study demonstrates that total IgGs isolated from IMNM patients have the aberrant capacity to enter muscle cells in the absence of complement. Further, a subset of patient IgGs exert direct pathogenic influences on engineered muscle contractile function that are independent of the complement system. Together, these findings have important implications for the advancement of IMNM precision medicine therapies.
Authors
- Yves Allenbach (ORCID: https://orcid.org/0000-0002-3185-7993)
- B. Tendrel
- Manish Kumar Singh (ORCID: https://orcid.org/0000-0001-7558-2656)
- Yekaterina Tiper (ORCID: https://orcid.org/0009-0001-6783-7652)
- Heta Lad
- Zhuoye Xie (ORCID: https://orcid.org/0000-0002-9111-6003)
- Alexandrine Mahoudeau (ORCID: https://orcid.org/0000-0003-0027-5402)
- Penney M. Gilbert (ORCID: https://orcid.org/0000-0001-5509-9616)
- Olivier Benveniste
- Ernest Myguel Esteban
Institutions
- Inserm (FR)
- University of Toronto (CA)
- Sorbonne Université (FR)
- Sorbonne Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Institut de Myologie (FR)
- Pitié-Salpêtrière Hospital (FR)
- Centre de Recherche en Myologie
Publication Details
- Journal
- Skeletal Muscle
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1186/s13395-025-00400-7
- Citations
- 1
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 1.35