Melatonin supplementation and outcomes of assisted reproductive technology: a systematic review and meta-analysis

As the outcomes of ART were influenced by multiple factors, MT supplementation may not significantly improve clinical pregnancy or live birth rate. However, MT appears to have a positive effect on oocyte and embryo quality, particularly in women with PCOS or decreased ovarian reserve (DOR), at least to some extent. Nevertheless, further well-designed, large-scale studies are needed before MT can be recommended for routine use in clinical practice.