Isotretinoin-Induced Raynaud's Phenomenon

Raynaud's phenomenon (RP) is characterized by color changes in the fingers and toes, typically triggered by cold or stress, and can occur as either a primary or secondary condition. Secondary Raynaud's phenomenon is associated with various underlying diseases, medications, and environmental factors. Isotretinoin, a widely used treatment for acne, is known for its potential side effects, but drug-induced RP remains an underrecognized complication. We present the case of a 20-year-old female who developed RP following the initiation of isotretinoin therapy for moderate acne, a reaction described as dose-dependent in some patients. This case highlights the potential for isotretinoin to induce RP and the importance of dose adjustment or discontinuation in managing this side effect.