A Case of Anti-3-Hydroxy-Methylglutaryl-Coenzyme a Reductase (Anti-HMGCR) Immune-Mediated Necrotizing Myopathy

Anti-3-hydroxy-methylglutaryl-coenzyme A reductase (Anti-HMGCR) immune-mediated necrotizing myopathy (INMN) is a type of autoimmune myopathy that is commonly associated with a history of statin use. In this case report, we present a 47-year-old man with a history of statin use who was admitted to the hospital with elevated creatine kinase and progressive muscle weakness. Muscle biopsy and myositis panel confirmed the diagnosis of anti-HMGCR IMNM. Creatine kinase levels and symptoms improved with the initiation of glucocorticoids, mycophenolate mofetil, and rituximab. This case report expresses the need for continued research into the treatment guidelines as well as the long-term effects of anti-HMGCR IMNM.