Revealing the key modules and potential prognostic markers of gastric cancer transformation based on weighted gene co-expression networks
WGCNA reveals modules associated with gastric precancerous lesions and cancer progression. <i>FCRL3</i>, <i>EFEMP1</i>, <i>ANKRD29</i>, and <i>STOX2</i> may serve as potential biomarkers for monitoring the transition from precancerous lesions to gastric cancer, offering insights into the mechanisms of gastric carcinogenesis and supporting early diagnosis and intervention strategies.
Authors
- Hao Gu (ORCID: https://orcid.org/0000-0002-3110-2531)
- Zhen Yang (ORCID: https://orcid.org/0000-0002-5011-1556)
- Heng Li (ORCID: https://orcid.org/0000-0002-3633-6679)
- Xiao–Ping Zhang (ORCID: https://orcid.org/0000-0001-5241-0069)
- Yufeng Zhao
- Haiyu Liu (ORCID: https://orcid.org/0000-0002-5348-2061)
- Wen Li (ORCID: https://orcid.org/0000-0003-0898-1264)
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-11-25
- DOI
- https://doi.org/10.3389/fgene.2025.1613682
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Academy of Chinese Medical Sciences