Baseline and follow-up change of cholesterol levels predict dementia risk and progression in older adults: a U-shaped relationship
Lipid instability, especially in HDL-c and TG, may serve as a marker of cognitive vulnerability. These findings suggest that longitudinal changes in serum cholesterol should be carefully monitored in older adults at risk of cognitive decline.
Authors
- Hsi‐Hsien Chou
- Hsin-Te Chang (ORCID: https://orcid.org/0000-0002-9985-9952)
- Hsin‐Hua Li
- Pai-Yi Chiu
- Chih‐Li Lin (ORCID: https://orcid.org/0000-0003-4553-3727)
- Hongming Chen (ORCID: https://orcid.org/0000-0002-8065-8333)
- Tzu‐Yu Chen
Institutions
- Chung Yuan Christian University (TW)
- Tunghai University (TW)
- Hsuan Chuang University (TW)
- Chung Shan Medical University Hospital (TW)
- Chang Bing Show Chwan Memorial Hospital (TW)
- National Taiwan University of Sport (TW)
- Chung Shan Medical University (TW)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1186/s13195-025-01910-8
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00