Quantitative Susceptibility Mapping in Skull Base Chordoma: In Silico Analysis and In Vivo Application Towards Indirect Hypoxia Assessment

This study provides a foundation for characterizing SBC through QSM, enabling indirect, non-invasive identification of potentially hypoxic tumor regions. Further histological validation with specific hypoxia markers, such as HIF-1α, is nevertheless required.

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Publication Details

Journal
Magnetic Resonance in Medicine
Published
2025-11-24
DOI
https://doi.org/10.1002/mrm.70193
Primary Topic
Bone Tumor Diagnosis and Treatments
Type
article
Field-Weighted Citation Impact
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article

Quantitative Susceptibility Mapping in Skull Base Chordoma: In Silico Analysis and In Vivo Application Towards Indirect Hypoxia Assessment

G. Baroni, Chiara Paganelli, Alberto Iannalfi, Sara Imparato et al.
Magnetic Resonance in Medicine
Bone Tumor Diagnosis and Treatments
article

Quantitative Susceptibility Mapping in Skull Base Chordoma: In Silico Analysis and In Vivo Application Towards Indirect Hypoxia Assessment

G. Baroni, Chiara Paganelli, Alberto Iannalfi, Sara Imparato, Ester M. Orlandi, Letizia Morelli, Sara Lillo, Giovanni Parrella, Paolo Fenech
article en

Abstract

This study provides a foundation for characterizing SBC through QSM, enabling indirect, non-invasive identification of potentially hypoxic tumor regions. Further histological validation with specific hypoxia markers, such as HIF-1α, is nevertheless required.

Magnetic Resonance in MedicineVol. 95(4)
University of Pavia (IT), National Center for Oncological Hadrontherapy (IT), Politecnico di Milano (IT)
Openalex Percentile: Top 48%
Bone Tumor Diagnosis and Treatments
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