Transfer Hydrogenation of In Situ Generated Imines Enables Functionalized Isatin‐Hydrazones
Herein, a transfer hydrogenation of in situ generated imine intermediates from readily available isatin-hydrazones with 1,4-benzoquinones or aldehydes by Brønsted acid catalysis was established. This efficient, mild ambient, operationally simple and safe approach afforded stereospecific functionalized isatin-3-arylhydrazones and isatin-3-alkylhydrazones in excellent yields (up to 95%).
Authors
- Dandan Zhu (ORCID: https://orcid.org/0000-0002-1683-3571)
- Fei Yu
- Yi Cai (ORCID: https://orcid.org/0000-0002-0853-2779)
- Junyi Ge (ORCID: https://orcid.org/0000-0002-4569-2915)
- Liu Song (ORCID: https://orcid.org/0009-0001-9090-1966)
- Qiao Shi
Institutions
- Chongqing University of Science and Technology (CN)
Publication Details
- Journal
- Chemistry - An Asian Journal
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1002/asia.202500666
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chongqing University
- Chongqing Science and Technology Commission
- Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission
- Chongqing University of Science and Technology