Balamuthia mandrillaris Encephalitis: Slow but Lethal March Towards the Brain
Balamuthia mandrillaris causes granulomatous amebic encephalitis. It is puzzling that unlike many blood-borne pathogens that can invade the central nervous system within hours, B. mandrillaris typically takes weeks to months before culminating in encephalitis. Here, we discuss basis of Balamuthia 's slow pathogenesis with an eye for improving early recognition, therapeutic interventions and identifying novel targets for intervention.
Authors
- Sutherland Kester Maciver (ORCID: https://orcid.org/0000-0001-8234-6061)
- Naveed Ahmed Khan (ORCID: https://orcid.org/0000-0001-7667-8553)
- Ruqaiyyah Siddiqui (ORCID: https://orcid.org/0000-0001-9646-6208)
Institutions
- Neurosciences Institute (US)
- University of Derby (GB)
- Heriot-Watt University (GB)
- MRC Centre for Regenerative Medicine (GB)
- Istinye University (TR)
- Derby College (GB)
- Institut Interdisciplinaire de Neuroscience (FR)
- University of Edinburgh (GB)
Publication Details
- Journal
- The Pediatric Infectious Disease Journal
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1097/inf.0000000000005057
- Primary Topic
- Legionella and Acanthamoeba research
- Type
- article
- Field-Weighted Citation Impact
- 0.00