Toremifene exerts chemopreventive effects against breast cancer through MTHFD1L suppression and ROS-mediated apoptosis
Toremifene exhibits potent chemopreventive activity by targeting MTHFD1L-mediated metabolic dysregulation and ROS-driven apoptosis, offering a promising alternative to tamoxifen for breast cancer prevention.
Authors
- Dong‐Xu Liu (ORCID: https://orcid.org/0000-0002-5949-7889)
- Peng Zhou (ORCID: https://orcid.org/0000-0002-6849-3855)
- Man Feng
- P. Song
- Maolin Guo (ORCID: https://orcid.org/0000-0002-9330-9239)
- Li Xu (ORCID: https://orcid.org/0000-0003-4405-1048)
- Yajie Zhou (ORCID: https://orcid.org/0009-0001-5450-3354)
- Zhigang Yu
- Xi–Shi Tai (ORCID: https://orcid.org/0000-0002-0050-1900)
- Xingchen Meng (ORCID: https://orcid.org/0000-0003-2846-7043)
- Chao Zheng (ORCID: https://orcid.org/0000-0002-5286-6485)
- Zhongbing Ma
- Zhaohui Li (ORCID: https://orcid.org/0000-0002-4132-658X)
- Linfeng Zhao (ORCID: https://orcid.org/0000-0003-3970-6337)
- Lin Chen (ORCID: https://orcid.org/0009-0007-9449-2876)
- Yuanheng Li
- Xingchen Zhou (ORCID: https://orcid.org/0000-0003-4245-4249)
- Lixiang Yu
- Yining Jia
Institutions
- Shandong University (CN)
- Second Hospital of Shandong University (CN)
- Affiliated Hospital of Shandong Academy of Medical Sciences (CN)
- Qilu Hospital of Shandong University (CN)
- Shandong First Medical University (CN)
- Shandong Center for Disease Control and Prevention (CN)
Publication Details
- Journal
- Chinese Medical Journal
- Published
- 2025-11-24
- DOI
- https://doi.org/10.1097/cm9.0000000000003886
- Citations
- 1
- Primary Topic
- Estrogen and related hormone effects
- Type
- article
- Field-Weighted Citation Impact
- 1.82