Sperm-Derived Extracellular Vesicles (Sperm-EVs), Emerging Biomarkers and Functional Modulators in Male Infertility and Assisted Reproduction
The available findings indicate that sperm-derived extracellular vesicles are significant functional regulators of sperm physiology and may serve as valuable non-invasive indicators for male infertility. The standardisation of EV isolation, characterisation, and clinical validation is essential prior to widespread use; nonetheless, their integration into liquid biopsy methods and assisted reproductive technology processes represents a significant improvement.
Authors
- Fotios Chatzinikolaou
- Panagiotis G. Antsaklis (ORCID: https://orcid.org/0000-0003-2106-5922)
- Despoina Mavrogianni (ORCID: https://orcid.org/0000-0003-1220-6594)
- Ioannis Papapanagiotou (ORCID: https://orcid.org/0000-0002-9723-5054)
- George K. Papadimas (ORCID: https://orcid.org/0000-0003-0163-4091)
- Aristotelis-Marios Koulakmanidis
- D. Loutradis (ORCID: https://orcid.org/0000-0002-8686-594X)
- Charalampos Voros (ORCID: https://orcid.org/0000-0001-9477-7619)
- Charalampos Τsimpoukelis
- Vasiliki Kanaka
- Kyriakos Bananis (ORCID: https://orcid.org/0000-0001-7563-4305)
- G. Daskalakis (ORCID: https://orcid.org/0000-0001-7108-211X)
- Maria Anastasia Daskalaki (ORCID: https://orcid.org/0000-0001-6377-8379)
- Marianna Theodora (ORCID: https://orcid.org/0000-0001-8280-7796)
- Aikaterini Athanasiou
- Nikolaos Thomakos
- Antonia Athanasiou
- Diamantis Athanasiou
- Dimitrios Vaitsis
- Spyridon Polykalas
- Maria Kanaka
Institutions
- National and Kapodistrian University of Athens (GR)
- Aristotle University of Thessaloniki (GR)
- King's College Hospital NHS Foundation Trust (GB)
- Alexandra Hospital (GR)
- Center for Human Reproduction (US)
Publication Details
- Journal
- Genes
- Published
- 2025-11-22
- DOI
- https://doi.org/10.3390/genes16121400
- Citations
- 3
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 2.42