Doxorubicin induces cardiotoxicity by enhancing autophagy via mTOR signaling in hiPSC- and hESC-derived cardiomyocytes
Our study uncovered the multifaceted effects of DOX on hiPSC-CMs and hESC-CMs, revealing a shared mechanism in which DOX enhances autophagy via inhibition of the mTOR signaling pathway. These findings reveal key insights into DIC pathogenesis and suggest that autophagy modulation may be a promising therapeutic strategy.
Authors
- Meng Ji (ORCID: https://orcid.org/0000-0002-1277-2118)
- Minxia Ke
- Nianmin Qi (ORCID: https://orcid.org/0000-0002-8580-0925)
- Hao Wang (ORCID: https://orcid.org/0000-0001-7475-0136)
- Yuehong Wu
- Kailun Yang (ORCID: https://orcid.org/0009-0003-3630-8197)
Institutions
- Zhejiang Sci-Tech University (CN)
- Zhejiang Lab (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-11-25
- DOI
- https://doi.org/10.3389/fcell.2025.1616235
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chinese Academy of Sciences
- Zhejiang University