Multimodal MRI reveals distinct hippocampal subregional alterations in de novo Parkinson’s disease across the cognitive spectrum
Dysfunction of left HIPm may contribute to initial executive decline in PD. The different subregions of the long-axis hippocampus could be targeted for early intervention strategies in PD with different cognitive states in the future.
Authors
- Jingru Ren (ORCID: https://orcid.org/0000-0002-9186-6621)
- Yang Shen (ORCID: https://orcid.org/0000-0003-3470-4324)
- Jiu Chen (ORCID: https://orcid.org/0000-0001-8185-8575)
- Chenxi Pan (ORCID: https://orcid.org/0000-0002-7485-7352)
- Gaiyan Zhou (ORCID: https://orcid.org/0000-0002-7135-5816)
- Yajie Wang (ORCID: https://orcid.org/0000-0001-7259-3886)
- Weiguo Liu (ORCID: https://orcid.org/0000-0001-5916-9837)
- Ronggui Zhang (ORCID: https://orcid.org/0000-0002-7720-3258)
- Emily Zhao (ORCID: https://orcid.org/0000-0002-4055-0774)
Institutions
- Tongji University (CN)
- Xuzhou Medical College (CN)
- The Central Hospital of Xiao gan (CN)
- Nanjing Brain Hospital (CN)
- Nanjing Drum Tower Hospital (CN)
- Second People’s Hospital of Huai’an (CN)
- Tongji Hospital (CN)
- Wuhan University of Science and Technology (CN)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-11-25
- DOI
- https://doi.org/10.3389/fnagi.2025.1685244
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Nanjing University
- National Key Research and Development Program of China