Pharmacogenetic variations and clinical implications of actionable CYP2D6/CYP2C19 variants in Central Indian patients with common mental disorders

This study demonstrates a high prevalence of actionable CYP2D6 and CYP2C19 variants in the Central Indian population, underscoring the need for pharmacogenetic integration in psychiatric prescribing in Indian clinical settings, to enhance treatment efficacy and minimize adverse events.

Authors

Santenna Chenchula (ORCID: https://orcid.org/0000-0001-7466-1037)
Tamonud Modak (ORCID: https://orcid.org/0000-0002-0876-2881)
Ratinder Jhaj (ORCID: https://orcid.org/0000-0002-3211-1122)
R Rozatkar Abhijit
Singh Jitendra
Kumari Komal
Atal Shubham
Balakrishnan Sadasivam
V. Satyaprakash

Institutions

All India Institute of Medical Sciences Bhopal (IN)

Publication Details

Journal: Frontiers in Pharmacology
Published: 2025-11-25
DOI: https://doi.org/10.3389/fphar.2025.1697866
Citations: 1
Primary Topic: Pharmacogenetics and Drug Metabolism
Type: article
Field-Weighted Citation Impact: 1.56

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article

Pharmacogenetic variations and clinical implications of actionable CYP2D6/CYP2C19 variants in Central Indian patients with common mental disorders

Santenna Chenchula, Tamonud Modak, Ratinder Jhaj, R Rozatkar Abhijit et al.

Nov 25, 2025

1 citations

Frontiers in Pharmacology

Pharmacogenetics and Drug Metabolism

1.56

article

Pharmacogenetic variations and clinical implications of actionable CYP2D6/CYP2C19 variants in Central Indian patients with common mental disorders

Santenna Chenchula, Tamonud Modak, Ratinder Jhaj, R Rozatkar Abhijit, Singh Jitendra, Kumari Komal, Atal Shubham, Balakrishnan Sadasivam, V. Satyaprakash

November 25, 2025article en

1 citations

Abstract

This study demonstrates a high prevalence of actionable CYP2D6 and CYP2C19 variants in the Central Indian population, underscoring the need for pharmacogenetic integration in psychiatric prescribing in Indian clinical settings, to enhance treatment efficacy and minimize adverse events.

Frontiers in PharmacologyVol. 16

All India Institute of Medical Sciences Bhopal (IN)

Openalex Percentile: Top 13%

Pharmacogenetics and Drug Metabolism

1.56

DOI Open Access PDF OpenAlex

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Pharmacogenetic variations and clinical implications of actionable CYP2D6/CYP2C19 variants in Central Indian patients with common mental disorders — Santenna Chenchula, Tamonud Modak, et al. · Frontiers in Pharmacology (2025) | TGRS Research Map | TGRS