Efficacy and safety of tranexamic acid combined with low molecular weight heparin versus fondaparinux sodium following total knee arthroplasty: a retrospective cohort study

TXA combined with LMWH demonstrates significant advantages over TXA combined with FPX in reducing overall complications, particularly MCVT, and lowering hospitalization costs, with favorable improvements in coagulation parameters. Both regimens showed comparable efficacy in managing perioperative blood loss, operative time, hospital stay, and transfusion requirements in TKA patients. Given the retrospective design and limited sample size, further validation through high-quality, large-scale prospective studies is warranted.