ER stress in D1-MSNs mediates cocaine-induced behavioral plasticity via the ATF4–SPTLC1 axis
These findings identify a D1-MSN ER stress response that promotes cocaine-induced neuroadaptations via the ATF4-SPTLC1 signaling axis and suggest a potential therapeutic target for cocaine addiction.
Authors
- Chunqi Liu
- Hong‐Chun Li (ORCID: https://orcid.org/0000-0001-9614-7119)
- Yinglan Zhao (ORCID: https://orcid.org/0000-0002-5168-5842)
- Yanping Dai (ORCID: https://orcid.org/0009-0002-7902-412X)
- Feng Qin (ORCID: https://orcid.org/0000-0001-9521-7146)
- Linhong Jiang (ORCID: https://orcid.org/0000-0003-1297-8797)
- Ying Zhao (ORCID: https://orcid.org/0000-0001-7293-8880)
- Weihong Kuang (ORCID: https://orcid.org/0000-0002-2392-4447)
- Qian Bu (ORCID: https://orcid.org/0000-0003-1316-2423)
- Meng Qin (ORCID: https://orcid.org/0000-0002-5448-2477)
- Yuanyi Zhou
- Yue Zhao (ORCID: https://orcid.org/0000-0002-3236-6360)
- Bin Liu (ORCID: https://orcid.org/0000-0002-8679-5638)
- Shu Li
- Liang Wang (ORCID: https://orcid.org/0000-0002-9364-8572)
- Rong Chen (ORCID: https://orcid.org/0000-0001-8315-4010)
- Yaxing Chen (ORCID: https://orcid.org/0000-0002-0406-8833)
- Xiaofeng Yang (ORCID: https://orcid.org/0000-0002-0675-305X)
- Bo Chen (ORCID: https://orcid.org/0000-0002-0079-4686)
- Shuang Han (ORCID: https://orcid.org/0000-0001-9736-0093)
- Xiaobo Cen
- Qingfan Wei
- Shunqing Xu (ORCID: https://orcid.org/0009-0004-0126-2034)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-25
- DOI
- https://doi.org/10.3389/fphar.2025.1677343
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Sichuan University
- Natural Science Foundation of Sichuan Province
- West China Hospital, Sichuan University