Beyond prescriptions: chronic medication adherence predicts mortality risk in a large-scale cohort study
The MARS is not generalisable across all groups, as evidenced by the absence of a monotonic trend in the overall sample. However, when combined with age, it effectively differentiated mortality risk for individuals aged 25-55. The standard fully underwritten model underestimated the number of deaths within this pharmacy population. The time-to-event analysis showed a significant inverse relationship between MARS category and survival time.
Authors
- Corrie Uys (ORCID: https://orcid.org/0000-0002-0313-3875)
- Dina C. Janse van Rensburg (ORCID: https://orcid.org/0000-0003-1058-6992)
- Natalie Schellack (ORCID: https://orcid.org/0000-0001-9690-6285)
- Audrey Jansen van Rensburg (ORCID: https://orcid.org/0000-0003-1749-5073)
- Jessica Hamuy Blanco (ORCID: https://orcid.org/0000-0002-8035-1438)
Institutions
- Cape Peninsula University of Technology (ZA)
- University of Pretoria (ZA)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-25
- DOI
- https://doi.org/10.3389/fphar.2025.1701588
- Primary Topic
- Medication Adherence and Compliance
- Type
- article
- Field-Weighted Citation Impact
- 0.00