Subacute edema progression after acute ischemic stroke: impact of intravenous alteplase administration and reperfusion degree
Alteplase administration prior to EVT did not impact the subacute edema progression in our cohort, whereas successful reperfusion was strongly associated with reduced edema progression, particularly at later timepoints. These results suggest that alteplase administration according to current guidelines is unlikely to contribute to accelerated edema progression and emphasize that achieving high-grade reperfusion is crucial for reducing secondary injury.
Authors
- Praneeta R. Konduri (ORCID: https://orcid.org/0000-0002-9911-2090)
- Laura M. van Poppel (ORCID: https://orcid.org/0000-0001-7921-2353)
- Ido R. van den Wijngaard (ORCID: https://orcid.org/0000-0002-3734-6086)
- Bart J. Emmer (ORCID: https://orcid.org/0000-0001-8462-4037)
- Henk A. Marquering (ORCID: https://orcid.org/0000-0002-1414-6313)
- Charles B.L.M. Majoie (ORCID: https://orcid.org/0000-0002-7600-9568)
- Ludo F.M. Beenen (ORCID: https://orcid.org/0000-0001-9204-1026)
- Robin Lemmens (ORCID: https://orcid.org/0000-0003-3374-1502)
- W Olszewski
- Fabiano Cavalcante (ORCID: https://orcid.org/0000-0003-2619-7182)
- Yvo B.W.E.M. Roos (ORCID: https://orcid.org/0000-0001-9205-5882)
Institutions
- Amsterdam University College (NL)
- Leiden University Medical Center (NL)
- Medisch Centrum Haaglanden (NL)
- Amsterdam Neuroscience (NL)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
- Stanford University (US)
- KU Leuven (BE)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-11-25
- DOI
- https://doi.org/10.3389/fneur.2025.1698480
- Citations
- 1
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 1.35