IgA expressed by glomerular mesangial cells is involved in the pathogenesis of IgA nephropathy
We reconfirmed the expression of IgA in GMCs and demonstrated that overexpression of Gd-IgA1 in GMCs induced by SEB through the TLR4 pathway in human GMC may play an important role in inducing an inflammatory response in IgAN.
Authors
- Yue Wang (ORCID: https://orcid.org/0000-0001-6636-354X)
- Yue-Ming Gao (ORCID: https://orcid.org/0000-0001-5640-3966)
- Lu Zhang (ORCID: https://orcid.org/0000-0001-8304-7055)
- Haidong Zhang (ORCID: https://orcid.org/0000-0003-2422-0182)
- Zhenling Deng (ORCID: https://orcid.org/0000-0002-0274-4594)
- Qi Li
Institutions
- Peking University (CN)
- Peking University Third Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-25
- DOI
- https://doi.org/10.3389/fimmu.2025.1638818
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00