Disruption of global brain network topology in amnestic MCI: evidence from multimodal DTI and fMRI
We identified a "structure-function dissociation" in aMCI, where the structural network suffers from fragmentation and hub disruption, while the functional network compensates through rigid, hyper-localized reorganization with elevated local efficiency. This divergence reveals a core pathological mechanism of the disease.
Authors
- Yingmei Han
- Zhangying Feng (ORCID: https://orcid.org/0000-0002-7881-6937)
- Ming Yang (ORCID: https://orcid.org/0000-0001-5307-8272)
- Hanxi Zhang (ORCID: https://orcid.org/0000-0002-2193-9581)
- Binjie Chu (ORCID: https://orcid.org/0000-0002-6430-2820)
- Wang Feng (ORCID: https://orcid.org/0000-0002-2248-5999)
- Weiqing Li (ORCID: https://orcid.org/0000-0002-1929-3654)
- Bai Xue (ORCID: https://orcid.org/0000-0001-8008-8425)
- Xinlu Li (ORCID: https://orcid.org/0000-0002-0766-4788)
- Qiu Feng Shang
Institutions
- Heilongjiang University of Chinese Medicine (CN)
- First Affiliated Hospital of Heilongjiang University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-11-25
- DOI
- https://doi.org/10.3389/fnins.2025.1675610
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00