miR-188-5p accelerates intervertebral disc degeneration by mediating P4HB to regulate ferroptosis in nucleus pulposus cells
Collectively, our findings establish miR-188-5p as a ferroptosis driver in IDD. Knockdown of miR-188-5p significantly upregulated P4HB expression, suppressed ferroptosis, and attenuated IDD progression. This study identifies miR-188-5p as a potential therapeutic target, providing a novel mechanistic framework for IDD treatment strategies.
Authors
- Quan Zhou (ORCID: https://orcid.org/0000-0002-9619-2187)
- Shuqing Miao
- Yi Gao (ORCID: https://orcid.org/0000-0003-3525-0133)
- Rui Chen (ORCID: https://orcid.org/0000-0002-2884-9896)
- Yin Zhu (ORCID: https://orcid.org/0000-0002-7561-2306)
- Ying Gong (ORCID: https://orcid.org/0000-0003-1451-4902)
- Jing Yan
Institutions
- Xuzhou Medical College (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1186/s40001-025-03530-2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00