Sporoderm-removed ganoderma lucidum spore powder (S-GLSP) alleviates neuroinflammation injury by regulating microglial polarization through inhibition of NLRP3 inflammasome activation
Our findings demonstrate that S-GLSP alleviates Alzheimer's disease pathology by inhibiting NLRP3 inflammasome activation, promoting a shift in microglial polarization from the M1 to the M2 phenotype, and modulating the release of inflammatory cytokines. This study provides novel mechanistic insights into the therapeutic potential of S-GLSP for AD.
Authors
- Wei Huang (ORCID: https://orcid.org/0000-0002-9744-8762)
- Yongchuan Yao (ORCID: https://orcid.org/0000-0002-5350-7193)
- Peng Zhou (ORCID: https://orcid.org/0000-0002-7322-692X)
- Biao Cai (ORCID: https://orcid.org/0000-0001-7355-0220)
- Shu Ye (ORCID: https://orcid.org/0000-0002-4126-4278)
- Wenli Li (ORCID: https://orcid.org/0000-0003-3279-3714)
Institutions
- Anhui University of Traditional Chinese Medicine (CN)
- Integrated Chinese Medicine (China) (HK)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-25
- DOI
- https://doi.org/10.3389/fphar.2025.1690192
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Anhui University
- Anhui University of Chinese Medicine