Optimization of cervical cord atrophy measurement using a real-world, multicentre dataset in multiple sclerosis
Clinical performance of CSA quantification regarding discrimination between rMS and pMS and correlations with EDSS was better for whole cervical cord (C1-7) than for C1-2 measurements, and for normalization by C1-C2 or C1-C3 vertebral height. Based on the quantitative results of this exploratory multi-center study and on previous literature, we formulated recommendations to support future study design decisions.
Authors
- Massimo Filippi (ORCID: https://orcid.org/0000-0002-5485-0479)
- Carsten Lukas (ORCID: https://orcid.org/0000-0002-8562-9697)
- Jaume Sastre‐Garriga (ORCID: https://orcid.org/0000-0002-1589-2254)
- Eva M. M. Strijbis (ORCID: https://orcid.org/0000-0001-6705-5864)
- Katrin Parmar (ORCID: https://orcid.org/0000-0002-4251-6238)
- Deborah Pareto (ORCID: https://orcid.org/0000-0001-7356-3769)
- Paola Valsasina (ORCID: https://orcid.org/0000-0001-5390-2655)
- Claudia A. M. Gandini Wheeler‐Kingshott (ORCID: https://orcid.org/0000-0002-4832-1300)
- Marios Yiannakas (ORCID: https://orcid.org/0000-0003-4986-446X)
- Iman Brouwer (ORCID: https://orcid.org/0000-0002-0408-0461)
- Àlex Rovira (ORCID: https://orcid.org/0000-0002-2132-6750)
- Frederik Barkhof (ORCID: https://orcid.org/0000-0003-3543-3706)
- Hugo Vrenken (ORCID: https://orcid.org/0000-0001-9106-1172)
- Maria Assunta Rocca (ORCID: https://orcid.org/0000-0003-2358-4320)
- Barbara Bellenberg (ORCID: https://orcid.org/0000-0001-7484-6787)
- Michael A�mann
- Ferran Prados
Institutions
- Universitat Oberta de Catalunya (ES)
- Vita-Salute San Raffaele University (IT)
- Queen Mary University of London (GB)
- University of Pavia (IT)
- University Hospital of Basel (CH)
- Centre for Biomedical Engineering and Physics (SE)
- Vall d'Hebron Hospital Universitari (ES)
- IRCCS Ospedale San Raffaele (IT)
- St. Josef-Hospital (DE)
- Amsterdam University Medical Centers (NL)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
- University College London (GB)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-11-26
- DOI
- https://doi.org/10.3389/fneur.2025.1657484
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bundesministerium für Bildung und Forschung
- Ruhr-Universität Bochum