Exploring therapeutic mechanism of Fuzhenghefuzhiyang Formula in psoriasis: inflammation and metabolism regulation
This study revealed that FZHFZY can effectively improve lesion conditions in a psoriasis-like mouse model, and its mechanism of action may be related to the association between purine metabolism, lipid metabolism, and key genes in the NLR signaling pathway.
Authors
- Xiangliang Deng (ORCID: https://orcid.org/0000-0002-7650-0509)
- Yonggen Chen (ORCID: https://orcid.org/0000-0002-8641-6749)
- Kexin Yang (ORCID: https://orcid.org/0000-0003-2333-2406)
- Chuanjian Lu (ORCID: https://orcid.org/0000-0001-6531-0702)
- Yujie Yang (ORCID: https://orcid.org/0000-0001-6069-0662)
- Hao Deng (ORCID: https://orcid.org/0000-0002-6417-6406)
- Chen Zhang (ORCID: https://orcid.org/0000-0003-0067-9271)
- Jingjie Yu
- Haiming Chen (ORCID: https://orcid.org/0000-0003-3417-6103)
- Bin Tang (ORCID: https://orcid.org/0000-0001-8986-040X)
- Haixin Zhong
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Guangdong Pharmaceutical University (CN)
- Guangzhou First People's Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-26
- DOI
- https://doi.org/10.3389/fimmu.2025.1690070
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Guangdong Provincial Hospital of Traditional Chinese Medicine
- National Natural Science Foundation of China