TMEM88 modulates the proliferation and metastasis of HCC via the GSK-3β/β-catenin pathway
This study suggests that TMEM88 may exert tumor-suppressive effects in HCC, potentially through modulation of the GSK-3β/β-catenin pathway, and its higher expression appears to be associated with more favorable outcomes. These findings indicate that TMEM88 could serve as a prognostic biomarker and may have therapeutic relevance, although further validation is required before clinical application.
Authors
- Hao Liao (ORCID: https://orcid.org/0000-0003-4392-8514)
- Jihao Zhang (ORCID: https://orcid.org/0000-0001-6192-4862)
- Linhui Peng
- Wenxin Li (ORCID: https://orcid.org/0000-0001-5235-9929)
- Xiuxiu Xuyun
- Jie Chen (ORCID: https://orcid.org/0000-0002-1678-3586)
- Tao Chen (ORCID: https://orcid.org/0000-0003-1306-6538)
- Yajin Chen (ORCID: https://orcid.org/0000-0002-4126-0357)
- Xi Chen (ORCID: https://orcid.org/0009-0007-9593-316X)
Institutions
- Sun Yat-sen University (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1186/s12885-025-15286-3
- Primary Topic
- Wnt/β-catenin signaling in development and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00