Associations of lifestyle factors with amyloid pathology in persons without dementia

BackgroundThe association between lifestyle factors and Alzheimer's disease (AD) pathophysiology remains incompletely understood.ObjectiveThe aim of this study was to assess the association of alcohol consumption, smoking behavior, sleep quality and physical, cognitive, and social activity with cerebral amyloid pathology.MethodsFor this cross-sectional study, we selected participants from the Amyloid Biomarker Study data pooling initiative. We used generalized estimating equations to assess associations of dichotomized lifestyle measures with amyloid pathology.ResultsWe included 9171 participants with normal cognition (NC) and 2555 participants with mild cognitive impairment (MCI) from the Amyloid Biomarker Study. Of participants with NC, 58% were women, 34% were <i>APOE</i> ε4 carrier, and 27% had amyloid pathology. Of participants with MCI, 48% were women, 47% were <i>APOE</i> ε4 carrier, and 57% had amyloid pathology. In NC, cognitively active participants were less likely to have amyloid pathology (OR = 0.77, 95%CI 0.66-0.89, p < 0.001). In MCI, participants who had ever smoked or had sleep problems were less likely to have amyloid pathology (OR = 0.85, 95%CI 0.73-0.99, p = 0.029; OR = 0.62, 95%CI 0.45-0.86, p = 0.004).ConclusionsIn NC, cognitive activity was associated with a lower frequency of amyloid pathology. In MCI, favorable lifestyle behaviors were not associated with a lower frequency of amyloid pathology. The results of the current study contribute to the broader evidence base on lifestyle and AD by further characterizing the role of lifestyle behaviors in AD pathology across different clinical stages.

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Journal
Journal of Alzheimer s Disease
Published
2025-11-13
DOI
https://doi.org/10.1177/13872877251379083
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
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0.00

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article

Associations of lifestyle factors with amyloid pathology in persons without dementia

Reisa Anne Sperling, Lisa Vermunt, Jens Wiltfang, Mark A. van Buchem et al.
Journal of Alzheimer s Disease
Dementia and Cognitive Impairment Research
article

Associations of lifestyle factors with amyloid pathology in persons without dementia

Reisa Anne Sperling, Lisa Vermunt, Jens Wiltfang, Mark A. van Buchem, Dina Silva, Juan Fortea, Simone Baiardi, Arantxa Juaristi, Oliver Peters, Lucilla Parnetti, Julius Popp, Randall John Bateman, Piero Parchi, Rik Ossenkoppele, Kaj Blennow, Eloy Rodríguez‐Rodríguez, Philip Scheltens, Lorena Rami, Adelina Orellana, Betty Marije Tijms, Mira Didic, Yaakov Stern, Wiesje M. van der Flier, Bjørn‐Eivind Kirsebom, Johannes Levin, Ramesh Kandimalla, Stefan Förster, Jayant Sakhardande, Alexandre de Mendonça, Nancy N. Maserejian, Philipp T. Meyer, Sebastiaan Engelborghs, Min Soo Byun, Lucrezia Hausner, Eric M. Reiman, Akitoshi Takeda, Eva Ntanasi, Christian Habeck, Pablo Martínez‐Lage, Anouk den Braber, Merçé Boada, Giovanni Battista Frisoni, Mary Yannakoulia, J. Jiménez‐Bonilla, Inez H.G.B. Ramakers, Elena Chipi, Julie Elisabeth Oomens, Ingmar Gr. Skoog, Catarina R. Oliveira, Aleksandra Klimkowicz‐Mrowiec, Isabel Santana, Nienke Legdeur, Gregory Scott Day, Lutz Fröhlich, Ricardo Allegri, Daniele Altomare, Johannes Kornhuber, Stephanie J. B. Vos, Éric Guedj, Pascual Sánchez‐Juan, Laura L. Ekblad, Luiza Spiru, Anna Zettergren, Yoshiaki Itoh, Matteo Pardini, Barbara Mroczko, Takeshi Iwatsubo, Charlotte Elisabeth Teunissen, Karen M. Rodrigue, Dahyun Yi, Nikolaos Scarmeas, Alexander Drzezga, Silke Kern, Hilkka Soininen, Willemijn J. Jansen, Wietse Wiels, Jakub Hort, Ron L. H. Handels, Lars Frings, Sylvia Villeneuve, Silvia Daniela Morbelli, Inês Baldeiras, Juha O. Rinne, Shinobu Minatani, Yvonne Freund‐Levi, Kewei Chen, Dong Young Lee, Gunhild Waldemar, Sabine Hellwig, Kiran Dip Gill, Jiří Cerman, Agustín Ruiz, Marta Marquié, Timo Grimmer, Åsa K. Wallin, Daniel Alcolea, Sudesh Prabhakar, Per Selnes, Tormod Fladby, Henrik Zetterberg, E. Rüther, W. Maier, Alberto Lleó, Susan M. Landau
article en

Abstract

BackgroundThe association between lifestyle factors and Alzheimer's disease (AD) pathophysiology remains incompletely understood.ObjectiveThe aim of this study was to assess the association of alcohol consumption, smoking behavior, sleep quality and physical, cognitive, and social activity with cerebral amyloid pathology.MethodsFor this cross-sectional study, we selected participants from the Amyloid Biomarker Study data pooling initiative. We used generalized estimating equations to assess associations of dichotomized lifestyle measures with amyloid pathology.ResultsWe included 9171 participants with normal cognition (NC) and 2555 participants with mild cognitive impairment (MCI) from the Amyloid Biomarker Study. Of participants with NC, 58% were women, 34% were <i>APOE</i> ε4 carrier, and 27% had amyloid pathology. Of participants with MCI, 48% were women, 47% were <i>APOE</i> ε4 carrier, and 57% had amyloid pathology. In NC, cognitively active participants were less likely to have amyloid pathology (OR = 0.77, 95%CI 0.66-0.89, p < 0.001). In MCI, participants who had ever smoked or had sleep problems were less likely to have amyloid pathology (OR = 0.85, 95%CI 0.73-0.99, p = 0.029; OR = 0.62, 95%CI 0.45-0.86, p = 0.004).ConclusionsIn NC, cognitive activity was associated with a lower frequency of amyloid pathology. In MCI, favorable lifestyle behaviors were not associated with a lower frequency of amyloid pathology. The results of the current study contribute to the broader evidence base on lifestyle and AD by further characterizing the role of lifestyle behaviors in AD pathology across different clinical stages.

Journal of Alzheimer s DiseaseVol. 108(3)
University of Geneva (CH), University of Copenhagen (DK), Jagiellonian University (PL), Brigham and Women's Hospital (US), Montreal Neurological Institute and Hospital (CA), Centre National de la Recherche Scientifique (FR), Biogen (United States) (US), University Hospital of North Norway (NO), Universidad de Cantabria (ES), Vrije Universiteit Brussel (BE), University of Bonn (DE), University of Wisconsin–Madison (US), Harvard University (US), Seoul National University (KR), University of Lisbon (PT), Medical University of Białystok (PL), University of Antwerp (BE), Emory University (US), Inserm (FR), University of Turku (FI), Gandhi Medical College & Hospital (IN), University of Freiburg (DE), Carol Davila University of Medicine and Pharmacy (RO), Turku University of Applied Sciences (FI), The University of Texas at Dallas (US), University of Eastern Finland (FI), Friedrich-Alexander-Universität Erlangen-Nürnberg (DE), Malmö University (SE), King's College London (GB), Neurosciences Institute (US), Lund University (SE), National and Kapodistrian University of Athens (GR), University of Zurich (CH), Washington University in St. Louis (US), Charles University (CZ), Heidelberg University (DE), Örebro University (SE), University of Perugia (IT), Douglas Mental Health University Institute (CA), Leiden University Medical Center (NL), Akershus University Hospital (NO), Sahlgrenska University Hospital (SE), University Medical Center Freiburg (DE), Instituto de Salud Carlos III (ES), German Center for Neurodegenerative Diseases (DE), Hospital de Sant Pau (ES), Turku University Hospital (FI), Hospitais da Universidade de Coimbra (PT), University Hospital Heidelberg (DE), Bayreuth Medical Center (DE), Centre Hospitalier Universitaire Vaudois (CH), Copenhagen University Hospital (DK), TUM Klinikum (DE), Rigshospitalet (DK), Karolinska Institutet (SE), LMU Klinikum (DE), Universitat Internacional de Catalunya (ES), Harokopio University of Athens (GR), Maastricht University (NL), Biomedical Research Networking Center on Neurodegenerative Diseases (ES), Kuopio University Hospital (FI), University Clinical Hospital In Bialystok (PL), University Hospital in Motol (CZ), Marqués de Valdecilla University Hospital (ES), International Longevity Centre (GB), University Hospital of Zurich (CH), Onze Lieve Vrouwziekenhuis Hospital (BE), Turku PET Centre (FI), Central Institute of Mental Health (DE), Amsterdam Neuroscience (NL), Institut de Neurosciences des Systèmes (FR), Institute for Neurodegenerative Disorders (US), Instituto de Investigación Marqués de Valdecilla (ES), Munich Cluster for Systems Neurology (DE), Hospital Clínic de Barcelona (ES), Universitätsmedizin Göttingen (DE), Instituto de Neurología Cognitiva (AR), Istituto delle Scienze Neurologiche di Bologna (IT), UK Dementia Research Institute (GB), Eginition Hospital (GR), Hertie Institute for Clinical Brain Research (DE), Centrale Méditerranée (FR), Ospedale Policlinico San Martino (IT), Mayo Clinic in Florida (US), Turku City Hospital (FI), Center for Pain and the Brain (US), National Hospital for Neurology and Neurosurgery (GB), Amsterdam University Medical Centers (NL), Fundacion CITA Alzheimer (ES), University Hospital Cologne (DE), Fundacion Centro De Investigacion De Enfermedades Neurologicas (ES), Hôpital de la Timone (FR), Banner Alzheimer’s Institute, Osaka Metropolitan University (JP), University College London (GB), Post Graduate Institute of Medical Education and Research (IN), McGill University (CA), Indian Institute of Chemical Technology (IN), Technical University of Munich (DE), Tokyo Metropolitan University (JP), University of Göttingen (DE), The University of Tokyo (JP), University of Coimbra (PT), UiT The Arctic University of Norway (NO), Columbia University (US), Charité - Universitätsmedizin Berlin (DE), University of Brescia (IT), University of Tübingen (DE), Ludwig-Maximilians-Universität München (DE), University of Genoa (IT), Vrije Universiteit Amsterdam (NL), University of Gothenburg (SE), University of Bologna (IT), University of California, Berkeley (US), University of Lausanne (CH)
U.S. Department of Defense, Alzheimer's Association, Bristol-Myers Squibb, Alzheimer's Drug Discovery Foundation, Eli Lilly and Company, Pfizer, Brigham and Women's Hospital, Biogen, University of Southern California, Alnylam Pharmaceuticals, Celgene, Meso Scale Diagnostics, Alzheimer's Disease Neuroimaging Initiative, Fundación BBVA, Familjen Erling-Perssons Stiftelse, Cure Alzheimer's Fund, BioClinica, Novartis Pharmaceuticals Corporation, McGill University, Fundació la Marató de TV3, Fondation Brain Canada, Japan Agency for Medical Research and Development, Northern California Institute for Research and Education, Stiftelsen för Gamla Tjänarinnor, EU Joint Programme – Neurodegenerative Disease Research, European Federation of Pharmaceutical Industries and Associations, Prothena, Apellis Pharmaceuticals, Amsterdam University Medical Centers, European Commission, Indian Council of Medical Research, Deutsche Forschungsgemeinschaft, ZonMw, Bundesministerium für Bildung und Forschung, Generalitat de Catalunya, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Korea Health Industry Development Institute, Eisai, Hjärnfonden, Novo Nordisk, Vetenskapsrådet, Leids Universitair Medisch Centrum, Banco Bilbao Vizcaya Argentaria, Deutsches Zentrum für Neurodegenerative Erkrankungen, Shionogi, Center for Translational Molecular Medicine, Radboud Universitair Medisch Centrum, Stichting Dioraphte, Innovative Medicines Initiative, Alzheimer Nederland, Siemens Healthineers, Servier, H. Lundbeck A/S, Ministry of Science and ICT, South Korea, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, IXICO, Grifols, Fleni, Amsterdam Neuroscience, Olav Thon Stiftelsen, GIESKES-STRIJBIS FONDS, National Institutes of Health, Genentech, HORIZON EUROPE Framework Programme, Canadian Institutes of Health Research, Japan Science and Technology Agency, Instituto de Salud Carlos III, European Regional Development Fund, Institut de Recherches Servier, National Institute on Aging, National Bioscience Database Center
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