Rejuvenation of mesenchymal stem cells by human peripheral blood lymphocytes
PBLs rejuvenate MSCs by promptly removing aged cells and enhancing the stemness and proliferative capacity of nonaged cells. This work provides an ideal method for obtaining substantial MSCs while meeting the quality requirements for stem cell therapy.
Authors
- Jun‐Wei Xu (ORCID: https://orcid.org/0000-0002-0871-2171)
- Jian‐Hui Xiao (ORCID: https://orcid.org/0000-0003-2563-9153)
- Yan Xu (ORCID: https://orcid.org/0000-0001-8986-8559)
- Jian‐Jiang Zhong (ORCID: https://orcid.org/0000-0002-2265-9338)
- Xinxin Zhu (ORCID: https://orcid.org/0000-0002-7303-8152)
- Xuemei Chen (ORCID: https://orcid.org/0000-0003-1588-127X)
- Wenting Chen (ORCID: https://orcid.org/0000-0003-4230-1189)
- Quang Hoan Le (ORCID: https://orcid.org/0000-0002-9798-0652)
- Yi Luo (ORCID: https://orcid.org/0000-0002-5388-2452)
- Huan Yuan (ORCID: https://orcid.org/0000-0001-6394-1703)
- Xu Yang (ORCID: https://orcid.org/0009-0004-2734-3203)
Institutions
- Kunming University of Science and Technology (CN)
- Zunyi Medical University (CN)
- Affiliated Hospital of Zunyi Medical College (CN)
Publication Details
- Journal
- BMC Biology
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1186/s12915-025-02472-9
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00