Trifluoromethylation of Arenes and Heterocycles via a Bench-Stable Photocaged Trifluoromethylation Reagent
Herein we report a simple radical aromatic trifluoromethylation process that utilizes a cationic aromatic sulfonate ester as a trifluoromethyl radical photocage. This chemistry allows for the rapid and straightforward trifluoromethylation of diverse aromatics and heterocycles, including complex pharmaceuticals and natural products, with only the substrate, photocage, solvent, and 456 nm light in minutes.
Authors
- Zi‐Hua Jiang (ORCID: https://orcid.org/0000-0001-5864-9249)
- Vishal Agarwal (ORCID: https://orcid.org/0000-0002-1179-1704)
- Bahar S. Heydari
- Vlad K. Kumirov (ORCID: https://orcid.org/0000-0002-8522-5617)
- Nicholas Kuehl (ORCID: https://orcid.org/0000-0003-3640-8596)
- Beeta Heydari
- Jeffrey L. Gustafson (ORCID: https://orcid.org/0000-0001-7054-7595)
- Michael T. Taylor (ORCID: https://orcid.org/0000-0002-7655-7222)
- Gavin J. Rustin (ORCID: https://orcid.org/0000-0001-5245-7932)
- Zhao Liu
- Penelope I. Dalton
- Isabella G. Najor
Institutions
- University of Arizona (US)
- San Diego State University (US)
- Stony Brook University (US)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1021/acs.orglett.5c04296
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00