DiaNat-DB-v2: A Molecular Database of Antidiabetic Compounds from Medicinal Plants and Functional Foods

Diabetes mellitus continues to be a significant health problem worldwide, and effective strategies and resources for its prevention and treatment are needed. Here, we present DiaNat-DB-v2, a refined and expanded version of the compound database that incorporates newly identified antidiabetic compounds from medicinal plants. By incorporating food-derived compounds, DiaNat-DB-v2 bridges the gap between medicinal chemistry and functional food research, creating new opportunities for nutraceutical development, personalized dietary interventions, and drug discovery. A comprehensive analysis of structural content, diversity, chemical space coverage, and safety-related metrics revealed that the updated database exhibits minimal overlap with FDA-approved drugs and contains a large proportion of unique molecular scaffolds, underscoring its originality and complementarity. Furthermore, the database has high natural-product likeness, a low incidence of structural alerts, and moderate compliance with classical druglikeness criteria. Together, these findings emphasize the value of DiaNat-DB-v2 as a resource for both health-oriented compound discovery and nutrition-focused research. DiaNat-DB-v2 is freely accessible as Supporting Information.