Identification of potential novel aromatase inhibitors as therapeutic strategies against breast cancer: insight into molecular docking, MD simulations and ADMET profiling
The three phytochemicals identified from Ricinus communis show promise as novel aromatase inhibitors with superior binding and favorable pharmacokinetic predictions compared to Letrozole. These compounds warrant further in vitro and in vivo study as potential breast cancer therapeutics.
Authors
- Mohammed H. AL Mughram (ORCID: https://orcid.org/0000-0002-7343-4083)
- Norah Hamdi
- Omar A. Almohammed (ORCID: https://orcid.org/0000-0002-3792-4106)
- Musaab Dauelbait (ORCID: https://orcid.org/0009-0003-0685-8243)
- Olayinka Abraham Ojedele
- Esmael M. Alyami
Institutions
- Federal University of Technology (NG)
- King Saud University (SA)
- Biotech Park (IN)
- King Khalid University (SA)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1186/s12885-025-15321-3
- Citations
- 1
- Primary Topic
- Estrogen and related hormone effects
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- King Saud University
- King Khalid University