Immune-Mediated Macular Edema After Intravitreal Methotrexate in Primary Vitreoretinal Lymphoma
The simultaneous inversion of the IL-10/IL-6 ratio with edema onset suggests a cytokine shift unmasking an inflammatory response previously suppressed by malignant lymphoproliferation. This pattern supports an immune reconstitution inflammatory syndrome-like mechanism as the most likely cause.
Authors
- Rita Pinto
- Sara Frazão (ORCID: https://orcid.org/0000-0002-8406-5295)
- Vanda Nogueira
- Rafaela Charles Correia
- Júlio Brissos
Institutions
- Public Risk Management Association (US)
Publication Details
- Journal
- Ocular Immunology and Inflammation
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1080/09273948.2025.2593458
- Citations
- 1
- Primary Topic
- CNS Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.39