Mild and Green Methodology for NIS-Mediated Synthesis of Quinoxalines from <i>o</i> -Phenylenediamines and Sulfoxonium Ylides at Room Temperature
An efficient, mild, green, and metal-free protocol for the synthesis of quinoxaline from sulfoxonium ylides and <i>o</i>-phenylenediamines in the presence of <i>N</i>-iodosuccinimide (NIS) at room temperature has been developed. This operationally simple protocol avoids hazardous catalysts or oxidants, tolerates diverse functional groups, and delivers products in good to excellent yields with high atom economy. The scalable procedure holds promise for applications across pharmaceuticals, biotechnology, materials science, and agriculture, offering an efficient route to novel bioactive molecules and cost-effective drug discovery.
Authors
- Mohmmad Younus Wani (ORCID: https://orcid.org/0000-0002-1838-1337)
- Mona O. Albalawi (ORCID: https://orcid.org/0009-0001-4594-8570)
- Humaira Parveen (ORCID: https://orcid.org/0000-0001-8365-0014)
- Sayeed Mukhtar (ORCID: https://orcid.org/0000-0002-5150-9187)
- Syed Khasim (ORCID: https://orcid.org/0000-0003-2710-9850)
Institutions
- Analytical Services (US)
- University of Jeddah (SA)
- Analytical Engineering (United States) (US)
- Institute of Organic Chemistry (HU)
- Laboratoire de Synthèse Organique (FR)
- Advanced Materials and Technologies (Slovenia) (SI)
- Czech Academy of Sciences, Institute of Analytical Chemistry (CZ)
- University of Tabuk (SA)
Publication Details
- Journal
- ACS Omega
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1021/acsomega.5c09337
- Primary Topic
- Synthesis and Biological Evaluation
- Type
- article
- Field-Weighted Citation Impact
- 0.00