Red Angico Gum: A Nontoxic Polysaccharide with Promising Antitumor and Antiedematogenic Activity

Polysaccharides are complex carbohydrates that play essential roles in several biological processes. The aim of this study was to isolate, characterize, and evaluate the cytotoxic, antitumor, and antiedematogenic potential <i>in vitro</i> and <i>in vivo</i> of red angico gum (RAG), a polysaccharide isolated from <i>Anadenanthera colubrina</i> var. <i>cebil</i> (Griseb.) Altschul. To confirm the chemical characteristics of RAG, nuclear magnetic resonance, size-exclusion chromatography, high-performance liquid chromatography analysis, and determination of uronic acid content by potentiometric titration were performed. RAG is composed mainly of arabinose and galactose with smaller proportions of rhamnose and glucuronic acid. <i>In vitro</i> cytotoxicity was determined by MTT and Alamar blue assays. For <i>in vivo</i> assays, mice bearing a sarcoma 180 tumor and the carrageenan-induced paw edema model were used to evaluate the antitumor and antiedematogenic effects. Hematological, biochemical, histopathological, and mutagenic analyses were performed to observe signs of toxicity after RAG administration. RAG did not show cytotoxicity <i>in vitro</i>; in contrast, it showed a significant tumor inhibition <i>in vivo</i> of up to 46.5%. Notably, such effects were observed without causing systemic and tissue toxicity in animals. Furthermore, RAG administration significantly reduced paw edema. These findings suggest that this polysaccharide exhibits antitumor and antiedematogenic potential in animal models, without showing signs of toxicity.

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Journal
ACS Omega
Published
2025-11-13
DOI
https://doi.org/10.1021/acsomega.5c09191
Citations
1
Primary Topic
Polysaccharides and Plant Cell Walls
Type
article
Field-Weighted Citation Impact
1.75
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article

Red Angico Gum: A Nontoxic Polysaccharide with Promising Antitumor and Antiedematogenic Activity

Nayze Lucena Sangreman Aldeman, Venícios Gonçalves Sombra, Irisvan S. Ribeiro, Débora Caroline do Nascimento Rodrigues et al.
1 citations
ACS Omega
Polysaccharides and Plant Cell Walls
1.75
article

Red Angico Gum: A Nontoxic Polysaccharide with Promising Antitumor and Antiedematogenic Activity

Nayze Lucena Sangreman Aldeman, Venícios Gonçalves Sombra, Irisvan S. Ribeiro, Débora Caroline do Nascimento Rodrigues, Maria Luísa Lima Barreto do Nascimento, Ana Jérsia Araújo, José Delano Barreto Marinho Filho, Fábio de Oliveira Silva Ribeiro, Rayran Walter Ramos de Sousa, Ingredy Lopes dos Santos, Regina C.M. de Paula, Dakson Douglas Araújo, Antonielly Campinho dos Reis, Durcilene Alves da Silva, Paulo Michel Pinheiro Ferreira
article en
1 citations

Abstract

Polysaccharides are complex carbohydrates that play essential roles in several biological processes. The aim of this study was to isolate, characterize, and evaluate the cytotoxic, antitumor, and antiedematogenic potential <i>in vitro</i> and <i>in vivo</i> of red angico gum (RAG), a polysaccharide isolated from <i>Anadenanthera colubrina</i> var. <i>cebil</i> (Griseb.) Altschul. To confirm the chemical characteristics of RAG, nuclear magnetic resonance, size-exclusion chromatography, high-performance liquid chromatography analysis, and determination of uronic acid content by potentiometric titration were performed. RAG is composed mainly of arabinose and galactose with smaller proportions of rhamnose and glucuronic acid. <i>In vitro</i> cytotoxicity was determined by MTT and Alamar blue assays. For <i>in vivo</i> assays, mice bearing a sarcoma 180 tumor and the carrageenan-induced paw edema model were used to evaluate the antitumor and antiedematogenic effects. Hematological, biochemical, histopathological, and mutagenic analyses were performed to observe signs of toxicity after RAG administration. RAG did not show cytotoxicity <i>in vitro</i>; in contrast, it showed a significant tumor inhibition <i>in vivo</i> of up to 46.5%. Notably, such effects were observed without causing systemic and tissue toxicity in animals. Furthermore, RAG administration significantly reduced paw edema. These findings suggest that this polysaccharide exhibits antitumor and antiedematogenic potential in animal models, without showing signs of toxicity.

ACS OmegaVol. 10(46)
Universidade Federal do Ceará (BR), Universidade Federal do Piauí (BR), HUN-REN Institute of Experimental Medicine (HU), Deoxi Biotecnologia (Brazil) (BR), Instituto de Ciência e Tecnologia de Polímeros (PT), Centro de Ingeniería Genética y Biotecnología (CU), Medicina (PL), Centro Regional de Derechos Humanos y Justicia de Género, Corporación Humanas (CL), Secretaria Municipal de Cultura (BR), Universidade Federal do Delta do Parnaíba
Openalex Percentile: Top 11%
Polysaccharides and Plant Cell Walls
1.75
DOIOpen Access PDFOpenAlex
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