SARS-CoV-2-ORF3a variant Q57H reduces its pro-apoptotic activity in host cells
The relatively mild phenotype of the SARS-CoV-2-ORF3a-Q57H variant may result from alterations to ORF3a function by this mutation, rather than its protein expression levels in host cells.
Authors
- Iuliia Polina
- Young Min Bae (ORCID: https://orcid.org/0000-0002-0635-0787)
- Byoung Doo Rhee (ORCID: https://orcid.org/0000-0002-9459-3227)
- Bong Sook Jhun (ORCID: https://orcid.org/0000-0001-9916-9962)
- Jin O‐Uchi (ORCID: https://orcid.org/0000-0001-7566-5400)
- Maria Landherr
- Isabel Chaput (ORCID: https://orcid.org/0000-0003-1890-3518)
- Michael W. Cypress
- Kye‐Im Jeon (ORCID: https://orcid.org/0000-0002-9180-3014)
- Bridget Nieto (ORCID: https://orcid.org/0009-0005-0751-8157)
- Sanjana Chandran
Institutions
- University of Minnesota (US)
- Chungbuk National University (KR)
- Konkuk University (KR)
- University of South Florida (US)
- Twin Cities Orthopedics (US)
Publication Details
- Journal
- F1000Research
- Published
- 2025-11-22
- DOI
- https://doi.org/10.12688/f1000research.146123.2
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- American Heart Association
- University of Minnesota
- University of South Florida
- National Institutes of Health
- National Heart, Lung, and Blood Institute